Transport Mode: Bus
- Companies: ADO, Estrella Blanca
 - Duration: Approximately 8 hours
 - Distance: 450 kilometers
 - Costs: Approximately 30 EUR (ticket prices may vary depending on the class)
 - Roads/Routes: Using the Mexican Highway 150D
 
Pro Tip: Opt for the first-class service of ADO for a more comfortable ride, which provides amenities like reclining seats and onboard snacks.
For a seamless journey from Orizaba, Veracruz to Guadalajara, Jalisco, taking a bus is the most practical and cost-efficient option. Ensure to book your tickets in advance via the ADO website or at the bus terminal to secure your seat, especially during peak travel seasons or holidays.