Car
- Companies: [Hertz], [Enterprise], [Budget]
- Duration: Approximately 5 hours 30 minutes
- Distance: 390 miles
- Costs: $60 for rental + $40 for gas = $100 (estimated)
- Roads/Routes: US-61 S, I-55 S, I-40 E
Pro Tip: When driving through Memphis, take a short detour to try some famous BBQ at Central BBQ – it’s worth the extra time!
For a scenic and comfortable trip from Cape Girardeau, MO to Nashville, TN, renting a car is a great option. With the flexibility of a vehicle, you can make stops and enjoy the beautiful scenery along the route. The journey will take you through charming towns and open highways, making it a leisurely weekend road trip.