Final Recommendation
If you are looking for the fastest and most efficient way to travel from Alexandria, MO to Mexico City, DF, I highly recommend taking a flight. The round-trip fares are reasonably priced, and the duration is much shorter compared to ground travel options, which could be quite lengthy due to multiple transfers and potential delays.
For a seamless experience, aim to book your flight with American Airlines or United Airlines, as they often offer competitive rates and good service. If you choose ground travel, ensure you plan your connections carefully to avoid long waiting times.