Train from Cape Girardeau to Milwaukee

Air

• Companies: Delta Airlines, American Airlines, Southwest Airlines
• Duration: Approximately 4 hours (including one layover)
• Distance: 670 miles (1,078 km)
• Costs: Approximately $300 - $450 CAD [tier-dependent]
• Roads/Routes: Not applicable

Pro Tip: Book your flight at least two months in advance to secure the best fares and consider flying mid-week for lower prices.

Bus

• Companies: Greyhound, Megabus
• Duration: Approximately 10-12 hours
• Distance: 670 miles (1,078 km)
• Costs: Approximately $100 - $150 CAD
• Roads/Routes: Interstate 55 North, Interstate 70 East, and Interstate 94 North

Pro Tip: Bring snacks and entertainment as bus travel can be lengthy; also check for WiFi availability on your bus.

Car

• Duration: Approximately 10 hours
• Distance: 670 miles (1,078 km)
• Costs: Approximately $100 - $120 CAD for gas and tolls
• Roads/Routes: Take I-55 N from Cape Girardeau, then merge onto I-70 E, and finally follow I-94 N to Milwaukee.

Pro Tip: Plan your gas stops using apps to find the best gas prices along your route.

Recommendation

For a balance of convenience and cost-efficiency, flying is the best option, especially when considering the overall time spent traveling. Utilize Delta Airlines, American Airlines, or Southwest Airlines for your journey, and don’t forget to book in advance for better fares. If you prefer scenic views and a more relaxed pace, driving allows you to make stops and explore along the way. Travelling via bus may also be an economical choice if you're looking for the lowest fare and are comfortable with a longer travel time.